Dietary Factors in the Modulation of Inflammatory Bowel Disease Activity

Shinil Shah, DO, PGY-1


March 27, 2007

Colostrums and Milk-Derived Peptide Growth Factors

Epidermal growth factor (EGF) has been shown to have positive effects in a trinitrobenzenesulfonic acid/ethanol model of colitis.[37] Colostrum, which contains certain cytokines such as platelet-derived growth factor, EGF, insulin-like growth factor, and transforming growth factor beta may therefore be beneficial in IBD.[38]

IGF-1 has been shown to promote gastrointestinal healing.[39] However, it is also a mitogen because it promotes cell growth, and because of the lack of large randomized controlled trials, caution should be exercised.[39] Of note, however, in an oral dextran sulphate sodium-induced model of colitis, short-term administration of IGF-1 was shown to have beneficial healing effects.[40] Another study showed that EGF enemas combined with oral mesalamine had a positive effect on ulcerative colitis disease activity.[41]


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