Dietary Factors in the Modulation of Inflammatory Bowel Disease Activity

Shinil Shah, DO, PGY-1


March 27, 2007

1, 25- Dihydrocholecalciferol

1, 25-dihydrocholecalciferol, the active form of vitamin D, has been shown in an IL-10 knock-out model of ulcerative colitis to reduce symptoms. This compound has been shown to be immunosuppressant, and has been shown to positively affect the disease process in a variety of diseases believed to be mediated by autoimmune processes. While a definite mechanism has not been fully elucidated, it is believed that 1, 25-dihydrocholecalciferol stimulates the production of transforming growth factor beta-1 and IL-4. These cytokines may suppress T-cell-mediated inflammatory activity.[34,35]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.