Dietary Factors in the Modulation of Inflammatory Bowel Disease Activity

Shinil Shah, DO, PGY-1

Disclosures

March 27, 2007

1, 25- Dihydrocholecalciferol

1, 25-dihydrocholecalciferol, the active form of vitamin D, has been shown in an IL-10 knock-out model of ulcerative colitis to reduce symptoms. This compound has been shown to be immunosuppressant, and has been shown to positively affect the disease process in a variety of diseases believed to be mediated by autoimmune processes. While a definite mechanism has not been fully elucidated, it is believed that 1, 25-dihydrocholecalciferol stimulates the production of transforming growth factor beta-1 and IL-4. These cytokines may suppress T-cell-mediated inflammatory activity.[34,35]

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