Effect of Oral Corticosteroids on Chronic Warfarin Therapy

Kathleen A. Hazlewood; Susan E. Fugate, PharmD BCPS CACP; Donald L. Harrison, PhD


The Annals of Pharmacotherapy. 2006;40(12):2101-2106. 

In This Article


Our study demonstrates a potentially significant interaction between chronic warfarin therapy and short-term use of prednisone and methylprednisolone. It provides additional substantiation to existing data of a drug class interaction between oral anticoagulants and corticosteroids. The interaction resulted in a significant increase in INR for the majority of patients in our study. However, the possibility of a decreased INR effect cannot be excluded. Therefore, empiric dose adjustments during concomitant therapy with these agents should not be made. Healthcare providers should closely monitor the INR in anticoagulated patients when corticosteroid therapy is initiated and make warfarin dose adjustments when necessary.

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