Gastrointestinal Plasmacytoma Causing Anemia in a Patient With Multiple Myeloma

Tuba Esfandyari; Susan C Abraham; Amindra S Arora


Nat Clin Pract Gastroenterol Hepatol. 2007;4(2):111-115. 

In This Article

Treatment and Management

Correct diagnosis of solitary plasmacytoma as the cause of gastrointestinal blood loss and anemia is important because localized plasmacytoma are radiosensitive. The treatment of choice for a localized, solitary plasmacytoma in the absence of osteolytic lesions or other features of multiple myeloma is tumoricidal radiation at a dose of 40 Gy over a 4-week period. Radiotherapy should also be given to the adjacent lymph nodes.[14]

Extranodal plasmacytoma in a patient with multiple myeloma carries a poor prognosis and treatment, which includes chemotherapy or autologous hematopoietic cell transplantation, is directed towards the underlying disease. The case patient received chemotherapy and autologous stem cell transplantation was planned. Neither option produces a cure, but adverse event free survival and overall survival are prolonged following autologous hematopoietic cell transplantation.[15]


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