New Insights Into Occupational Asthma

Louis-Philippe Boulet; Catherine Lemiére; Denyse Gautrin; André Cartier

Disclosures

Curr Opin Allergy Clin Immunol. 2007;7(1):96-101. 

In This Article

Abstract and Introduction

Abstract

Purpose of review: To examine recent publications on the types of agents involved in occupational asthma, the mechanisms by which they induce asthma, and how best to evaluate and treat workers suspected of this respiratory condition.
Recent findings: High rates of occupational asthma and inhalation accidents were found in workers in crafts and related occupations in the manufacturing industries, and in plant and machine operatives; cleaners and construction workers may also be at risk. Further data support a role for CD4+ T cells in low-molecular-weight agent-induced asthma, such as with isocyanates, and neurogenic mechanisms may also be involved. The use of noninvasive measures of airway inflammation in the diagnosis and management of occupational asthma such as sputum eosinophils monitoring is promising, although this is less obvious for exhaled nitric oxide. Finally, the persistence of troublesome asthma even after withdrawal from relevant exposure has been re-emphasized and surveillance programs have been proposed.
Summary: Further data have been gathered on the prevalence of occupational asthma in various working populations, its mechanisms of development, the contribution of noninvasive measures of airway inflammation in the diagnosis and management of this condition, and its management and prevention.

Introduction

About 9-15% of adult-onset asthma is considered attributable to occupational exposures.[1,2] Although a large number of agents have been identified as potential inducers of occupational asthma, various working populations remain to be tested with regard to the prevalence of such a health hazard. Furthermore, we need to know more about the mechanisms by which these agents induce asthma, and how best to evaluate and treat workers suspected of this respiratory condition.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....