Severe Acute Respiratory Syndrome in Children

Lauren J. Stockman, MPH*†; Mehran S. Massoudi, PhD, MPH*; Rita Helfand, MD*; Dean Erdman, DrPH*; Alison M. Siwek, MPH*†; Larry J. Anderson, MD*; Umesh D. Parashar, MD, MPH*


Pediatr Infect Dis J. 2007;26(1):68-74. 

In This Article


Some important caveats should be noted in interpretation of the findings of this review. First, we have summarized a variety of data collected by investigators in different countries without use of standardized data collection instruments, methods of assessment and management of patients, and diagnostic case definitions. Without consistent laboratory confirmation, these descriptions are likely to include cases that were not caused by SARS-CoV. Second, steroids and antiviral agents were used widely as empiric treatments for SARS in both adults and children. Although the effectiveness of these therapies is unknown, as a result of their use, many observed parameters such as biochemical levels and time required for chest radiograph resolution during the course of illness may not reflect the true natural history of SARS. We limited this review to English publications to allow us to review each case series consistently. However, experience with pediatric SARS appears to be similar across affected countries and is likely reflected by what has been published in the English literature.


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