Epidemics After Natural Disasters

John T. Watson; Michelle Gayer; Maire A. Connolly

Disclosures

Emerging Infectious Diseases. 2007;13(1) 

In This Article

Communicable Diseases Associated with Natural Disasters

The following types of communicable diseases have been associated with populations displaced by natural disasters. These diseases should be considered when postdisaster risk assessments are performed.

Water-related Communicable Diseases

Access to safe water can be jeopardized by a natural disaster. Diarrheal disease outbreaks can occur after drinking water has been contaminated and have been reported after flooding and related displacement. An outbreak of diarrheal disease after flooding in Bangladesh in 2004 involved >17,000 cases; Vibrio cholerae (O1 Ogawa and O1 Inaba) and enterotoxigenic Escherichia coli were isolated.[13] A large (>16,000 cases) cholera epidemic (O1 Ogawa) in West Bengal in 1998 was attributed to preceding floods,[14] and floods in Mozambique in January-March 2000 led to an increase in the incidence of diarrhea.[15]

In a large study undertaken in Indonesia in 1992-1993, flooding was identified as a significant risk factor for diarrheal illnesses caused by Salmonella enterica serotype Paratyphi A (paratyphoid fever).[16] In a separate evaluation of risk factors for infection with Cryptosporidium parvum in Indonesia in 2001-2003, case-patients were >4x more likely than controls to have been exposed to flooding.[17]

The risk for diarrheal disease outbreaks following natural disasters is higher in developing countries than in industrialized countries.[8,11] In Aceh Province, Indonesia, a rapid health assessment in the town of Calang 2 weeks after the December 2004 tsunami found that 100% of the survivors drank from unprotected wells and that 85% of residents reported diarrhea in the previous 2 weeks.[18] In Muzaffarabad, Pakistan, an outbreak of acute watery diarrhea occurred in an unplanned, poorly equipped camp of 1,800 persons after the 2005 earthquake. The outbreak involved >750 cases, mostly in adults, and was controlled after adequate water and sanitation facilities were provided.[19] In the United States, diarrheal illness was noted after Hurricanes Allison[20] and Katrina,[21,22,23] and norovirus, Salmonella, and toxigenic and nontoxigenic V. cholerae were confirmed among Katrina evacuees.

Hepatitis A and E are also transmitted by the fecal-oral route, in association with lack of access to safe water and sanitation. Hepatitis A is endemic in most developing countries, and most children are exposed and develop immunity at an early age. As a result, the risk for large outbreaks is usually low in these settings. In hepatitis E-endemic areas, outbreaks frequently follow heavy rains and floods; the illness is generally mild and self-limited, but for pregnant women case-fatality rates can reach 25%.[24] After the 2005 earthquake in Pakistan, sporadic hepatitis E cases and clusters were common in areas with poor access to safe water. Over 1,200 cases of acute jaundice, many confirmed as hepatitis E, occurred among the displaced.[25] Clusters of both hepatitis A and hepatitis E were noted in Aceh after the December 2004 tsunami.[26]

Leptospirosis is an epidemic-prone zoonotic bacterial disease that can be transmitted by direct contact with contaminated water. Rodents shed large amounts of leptospires in their urine, and transmission occurs through contact of the skin and mucous membranes with water, damp soil or vegetation (such as sugar cane), or mud contaminated with rodent urine. Flooding facilitates spread of the organism because of the proliferation of rodents and the proximity of rodents to humans on shared high ground. Outbreaks of leptospirosis occurred in Taiwan, Republic of China, associated with Typhoon Nali in 2001;[27] in Mumbai, India, after flooding in 2000;[28] in Argentina after flooding in 1998;[29] and in the Krasnodar region of the Russian Federation in 1997.[30] After a flooding-related outbreak of leptospirosis in Brazil in 1996, spatial analysis indicated that incidence rates of leptospirosis doubled inside the flood-prone areas of Rio de Janeiro.[31]

Diseases Associated with Crowding

Crowding is common in populations displaced by natural disasters and can facilitate the transmission of communicable diseases. Measles and the risk for transmission after a natural disaster are dependent on baseline immunization coverage among the affected population, and in particular among children <15 years of age. Crowded living conditions facilitate measles transmission and necessitate even higher immunization coverage levels to prevent outbreaks.[32] A measles outbreak in the Philippines in 1991 among persons displaced by the eruption of Mt. Pinatubo involved >18,000 cases.[33] After the tsunami in Aceh, a cluster of measles involving 35 cases occurred in Aceh Utara district, and continuing sporadic cases and clusters were common despite mass vaccination campaigns.[26] In Pakistan, after the 2005 South Asia earthquake, sporadic cases and clusters of measles (>400 clinical cases in the 6 months after the earthquake) also occurred.[25]

Neisseria meningitidis meningitis is transmitted from person to person, particularly in situations of crowding. Cases and deaths from meningitis among those displaced in Aceh and Pakistan have been documented.[25,26] Prompt response with antimicrobial prophylaxis, as occurred in Aceh and Pakistan, can interrupt transmission. Large outbreaks have not been recently reported in disaster-affected populations but are well-documented in populations displaced by conflict.[34]

Acute respiratory infections (ARI) are a major cause of illness and death among displaced populations, particularly in children <5 years of age. Lack of access to health services and to antimicrobial agents for treatment further increases the risk for death from ARI. Risk factors among displaced persons include crowding, exposure to indoor cooking using open flame, and poor nutrition. The reported incidence of ARI increased 4-fold in Nicaragua in the 30 days after Hurricane Mitch in 1998,[35] and ARI accounted for the highest number of cases and deaths among those displaced by the tsunami in Aceh in 2004[26] and by the 2005 earthquake in Pakistan.[25]

Vectorborne Diseases

Natural disasters, particularly meteorologic events such as cyclones, hurricanes, and flooding, can affect vector-breeding sites and vectorborne disease transmission. While initial flooding may wash away existing mosquito-breeding sites, standing water caused by heavy rainfall or overflow of rivers can create new breeding sites. This situation can result (with typically some weeks' delay) in an increase of the vector population and potential for disease transmission, depending on the local mosquito vector species and its preferred habitat. The crowding of infected and susceptible hosts, a weakened public health infrastructure, and interruptions of ongoing control programs are all risk factors for vectorborne disease transmission.[36]

Malaria outbreaks in the wake of flooding are a well-known phenomenon. An earthquake in Costa Rica's Atlantic Region in 1991 was associated with changes in habitat that were beneficial for breeding and preceded an extreme rise in malaria cases.[37] Additionally, periodic flooding linked to El Niño-Southern Oscillation has been associated with malaria epidemics in the dry coastal region of northern Peru.[38]

Dengue transmission is influenced by meteorologic conditions, including rainfall and humidity, and often exhibits strong seasonality. However, transmission is not directly associated with flooding. Such events may coincide with periods of high risk for transmission and may be exacerbated by increased availability of the vector's breeding sites (mostly artificial containers) caused by disruption of basic water supply and solid waste disposal services. The risk for outbreaks can be influenced by other complicating factors, such as changes in human behavior (increased exposure to mosquitoes while sleeping outside, movement from dengue-nonendemic to -endemic areas, a pause in disease control activities, overcrowding) or changes in the habitat that promote mosquito breeding (landslide, deforestation, river damming, and rerouting of water).

Other Diseases Associated with Natural Disasters

Tetanus is not transmitted person to person but is caused by a toxin released by the anaerobic tetanus bacillus Clostridium tetani. Contaminated wounds, particularly in populations where vaccination coverage levels are low, are associated with illness and death from tetanus. A cluster of 106 cases of tetanus, including 20 deaths, occurred in Aceh and peaked 2 1/2 weeks after the tsunami.[26] Cases were also reported in Pakistan following the 2005 earthquake.[25]

An unusual outbreak of coccidiomycosis occurred after the January 1994 Southern California earthquake. The infection is not transmitted person to person and is caused by the fungus Coccidioides immitis, which is found in soil in certain semiarid areas of North and South America. This outbreak was associated with exposure to increased levels of airborne dust subsequent to landslides in the aftermath of the earthquake.[39]

Disaster-related Interruption of Services

Power cuts related to disasters may disrupt water treatment and supply plants, thereby increasing the risk for waterborne diseases. Lack of power may also affect proper functioning of health facilities, including preservation of the vaccine cold chain. An increase in diarrheal illness in New York City followed a massive power outage in 2003. The blackout left 9 million people in the area without power for several hours to 2 days. Diarrhea cases were widely dispersed and detected by using nontraditional surveillance techniques. A case-control study performed as part of the outbreak investigation linked diarrheal illness with the consumption of meat and seafood after the onset of the power outage, when refrigeration facilities were widely interrupted.[40]

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