We found that adult offspring of BEN patients have an average increased blood systolic pressure and pulse pressure, determined in two repeated measurement one year apart. This is contrary to reports in BEN patients, who do not have this characteristic. Surprisingly, the increase was related to a maternal history of BEN, or a history of BEN in both parents, but not to a paternal history alone. Increased blood pressure was also associated with a reduction of the minimal width of the kidney cortex, but not with a reduction in kidney length. In our understanding, these findings emphasize the role of maternal priming in determining susceptibility for increased blood pressure. Balkan endemic nephropathy may serve as a model to better understand the development of both kidney disorders and their related blood pressures.
The authors thank Susan Davis for suggestions on the manuscript.Funding information
Disclosure: This research was supported by the National Institutes of Health, USA, Research Grant # R01 TW006192 (Fogarty International Center and the National Institute of Environmental Health Sciences), awarded to the National Center of Public Health Protection, Sofia, Bulgaria.
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Cite this: Increased Blood Pressure in Adult Offspring of Families With Balkan Endemic Nephropathy: A Prospective Study - Medscape - Aug 01, 2006.