Biological Response Modifiers in Cancer

Purabi Reang, MD; Madhur Gupta, MD; Kamlesh Kohli, MD

Disclosures

November 14, 2006

Epratuzumab

Epratuzumab (LL2) is a murine IgG2a antibody targeted against CD22 antigen (transferrin receptor). It is widely expressed during B-cell development and is present in most of NHL tumours[64] Juweid and colleagues[65] compared 131ILL2 with 90Y LL2 in patients with relapsed/refractory NHL. 90Y LL2 treatment was found to be more effective than 131I LL2, the objective tumor response being 29% and 15%, respectively, with these treatments.

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