Immune Suppression and Colorectal Cancer

C. Evans; A. G. Dalgleish; D. Kumar

Disclosures

Aliment Pharmacol Ther. 2006;24(8):1163-1177. 

In This Article

Impaired NK Activity

Natural killer cells are critical to innate immunity, performing an immunosurveillance function through recognition of altered or missing self on damaged, infected, or transformed malignant cells.[189] They can act against tumour initiation, growth and metastasis; suppressing tumour cells through a variety of effector mechanisms, including the perforin/granzyme-containing granule-mediated pathway, death-receptor pathway and IFN-γ-mediated pathway.[190]

Patients with colorectal cancer have suppressed NK cell activity,[191,192,193,194,195] which is an important prognostic factor for the development of distant metastases,[192,193,194] and is reversed postcurative resection.[195] The modulation of NK responses is believed to occur through downregulating surface expression of the NK's activating NKG2D receptors and chemokine CXCR1 receptors.[166,196]

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