Clinical Hypogonadism and Androgen Replacement Therapy: An Overview

Dana A. Ohl; Susanne A. Quallich


Urol Nurs. 2006;26(4):253-259,269. 

In This Article

Testosterone Replacement

Hormone replacement therapy for men should be considered when clinical complaints are accompanied by decreased hormone levels. It would seem intuitive that it should be replaced if the clinical picture is consistent with the accepted description for ADAM. Common goals of treatment are to re-establish sexual functioning, libido, and improve overall mood (Morales et al., 2000). Restoration of normal testosterone levels can also improve muscle mass, prevent osteoporosis, maintain mental acuity, and maintain virilization, especially in elderly males. Prevention of osteoporosis alone can greatly decrease both morbidity and mortality in aged men due to hip fractures (Vermeulen, 2001). It remains unclear as to what target level they should be treated, as even in young men it is not clear if normal testosterone levels are needed for the full anabolic and androgenic benefits of testosterone (Vermeulen, 2001).

The presence of prostate cancer or male breast cancer is an absolute contraindication for testosterone replacement treatment. Severe obstructive uropathy is a relative contraindication.


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