Wilson's Disease: An Update

Shyamal K Das; Kunal Ray


Nat Clin Pract Neurol. 2006;2(9):482-493. 

In This Article

Disease Prognosis

WD has a fatal outcome if not treated appropriately and in a timely manner. Symptomatic WD patients require lifelong treatment, because an interruption to therapy or inadequate treatment can lead to fatalities within 9 months to 3 years.[24] The severity of disease at the start of treatment determines the level of disability, and an early onset is worse than a late onset in terms of prognosis. If treatment is begun early enough, symptomatic recovery is usually complete, leading to a normal life expectancy. Residual dysarthria and mild dystonia are relatively common in neurological WD (SK Das, personal experience). A prognostic index using the Nazer score has been proposed to differentiate between fatal and nonfatal cases of WD, and is based on the severity of the abnormality of serum aspartate aminotransferase, bilirubin and prothrombin time at admission.[61]


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