Effects of Duration of Type 2 Diabetes Mellitus on Insulin Secretion

Farhad Zangeneh, MD; Puneet S. Arora, MD; Peter J. Dyck, MD; Lynn Bekris; Ake Lernmark, PhD; Sara J. Achenbach; Ann L. Oberg, PhD; Robert A. Rizza, MD


Endocr Pract. 2006;12(4):388-393. 

In This Article


The data from this study support the widely held belief that insulin secretion decreases over time in patients with type 2 diabetes mellitus. They also indicate, however, that the rate of decline of insulin secretion, as assessed by fasting and postglucagon C-peptide concentrations, can be variable within a specific individual and that decline does not occur in all patients; thus, the predictive value of any single measurement is limited. Collectively, these data indicate that even though a decrease in insulin secretion over time is characteristic of type 2 diabetes mellitus, it is not inevitable. Therefore, the effectiveness of therapies designed to preserve or increase beta cell function varies from one patient to another.


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