Effects of Duration of Type 2 Diabetes Mellitus on Insulin Secretion

Farhad Zangeneh, MD; Puneet S. Arora, MD; Peter J. Dyck, MD; Lynn Bekris; Ake Lernmark, PhD; Sara J. Achenbach; Ann L. Oberg, PhD; Robert A. Rizza, MD

Disclosures

Endocr Pract. 2006;12(4):388-393. 

In This Article

Conclusion

The data from this study support the widely held belief that insulin secretion decreases over time in patients with type 2 diabetes mellitus. They also indicate, however, that the rate of decline of insulin secretion, as assessed by fasting and postglucagon C-peptide concentrations, can be variable within a specific individual and that decline does not occur in all patients; thus, the predictive value of any single measurement is limited. Collectively, these data indicate that even though a decrease in insulin secretion over time is characteristic of type 2 diabetes mellitus, it is not inevitable. Therefore, the effectiveness of therapies designed to preserve or increase beta cell function varies from one patient to another.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....