Lobular Neoplasia in Breast Core Needle Biopsy Specimens Is Associated With a Low Risk of Ductal Carcinoma In Situ or Invasive Carcinoma on Subsequent Excision

Andrew A. Renshaw, MD; Robert P. Derhagopian, MD; Pilar Martinez, MD; Edwin W. Gould, MD


Am J Clin Pathol. 2006;126(2):310-313. 

In This Article

Materials and Methods

The results of breast core needle biopsy specimens interpreted from September 1, 2001, to January 31, 2006, at Baptist Hospital of Miami, Miami, FL, were reviewed. Cases from our previous study[12] were not included. All biopsy specimens with a diagnosis of LN (ALH or LCIS) were identified. Additional lesions identified in the biopsy specimen also were identified. These included the presence of DCIS or IC, mucocele-like lesions, and atypical ductal hyperplasia (ADH). Criteria for ADH were those identified by others.[13] In brief, these lesions were restricted to intraductal proliferations with some, but not sufficient, features of DCIS. The criteria for LN were those outlined by others.[14,15]

Cases of LN were divided into ALH and LCIS. In addition, cases with larger cells than normal, ie, pleomorphic LN, also were identified. In cases in which tissue was available in the core needle biopsy specimen for immunohistochemical analysis, E-cadherin testing was performed as detailed elsewhere.[16]

All breast core needle biopsy specimens were obtained by the clinicians. More than 95% were performed by the radiology department and consisted almost exclusively of 11- and 14-gauge core needle biopsy specimens obtained under ultrasound or stereotactic guidance.

All specimens were received fixed and routinely processed. Up to 5 cores were processed in a single block; if more than 5 cores were present, an additional block was prepared. Each block was sectioned entirely to produce at least 5 slides and 2 levels per slide.[17]

Additional tissue follow-up was obtained from the records of the Baptist Hospital pathology department.

Statistical analysis was performed using a 2-tailed Fisher exact test.


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