Key Articles, Guidelines, and Consensus Papers Relative to the Treatment of Dyslipidemias-2005

Matthew K. Ito, Pharm.D., FCCP; Rebecca J. Cheung, Pharm.D.; Eric K. Gupta, Pharm.D.; Kimberly K. Birtcher, Pharm.D.; Pang H. Chong, Pharm.D.; Theresa M. Bianco, Pharm.D.; Barry E. Bleske, Pharm.D., FCCP

Disclosures

Pharmacotherapy. 2006;26(7):939-1010. 

In This Article

Abstract and Introduction

Hypercholesterolemia is a major risk factor for development of coronary heart disease. Proper diagnosis and adequate treatment are vital to reducing morbidity and mortality associated with elevated serum lipid levels. The amount of literature in this area is overwhelming. To aid practitioners and educators in organizing this large body of information, we compiled key articles, guidelines, and consensus papers relative to the treatment of dyslipidemias. Research articles were chosen based on the significance of findings, relevance to practice, quality of research, and timeliness; recent articles were given priority over earlier ones unless they demonstrated groundbreaking findings.

Coronary heart disease (CHD) is the leading cause of death in the United States and other industrialized nations and is the chief cause of premature, permanent disability in the workforce. Hypercholesterolemia is a major risk factor for development of CHD. Thus, it is not surprising that cholesterol is the most "decorated" molecule in history, having contributed to as many as 13 Nobel prizes.[1] In the past 20 years, major strides have been made in the understanding and treatment of hypercholesterolemia and other dyslipidemias. Since its inception in 1985, the National Cholesterol Education Program (NCEP) has battled to reduce the prevalence of high blood cholesterol through educational campaigns and science-based practice guidelines.[2] However, cholesterol levels are still undertreated.[3]

The body of literature presented here provides a source of important references and practice guidelines for clinicians seeking to broaden their knowledge regarding treatment of dyslipidemias. Research articles were chosen based on significance of findings, relevance to practice, quality of research, and timeliness; recent articles were given priority over earlier ones unless they demonstrated groundbreaking findings. Selected review articles were included for their comprehensive overview and state-of-the-art perspective.

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