Testosterone Replacement Therapy and the Risk of Prostate Cancer. Is There a Link?

A. Barqawi; E. D. Crawford


Int J Impot Res. 2006;18(4):323-328. 

In This Article


In spite of the theoretical increase in prostate cancer risk following TRT, there is currently no evidence that testosterone administration can initiate or promote a de novo or pre-existing prostatic malignancy in hypogonadal men.[40] In fact, there are strong indications that normal testosterone levels play a protective role in the natural history of prostate cancer. Many studies have demonstrated that a low testosterone level prior to treatment is an independent predictor of a more aggressive, high-grade cancer,[20] an increased likelihood of extraprostatic disease at the time of diagnosis,[41] and a decreased likelihood of a favorable treatment response.[42] Nevertheless, most of these trials are limited in sample size and duration of therapy. Therefore, until the true risk of TRT has been established in long-term studies, it is crucial to carefully screen and closely monitor these men for occult prostate cancer.

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