June 3, 2006 – Treatment with potent D2-receptor antagonists such as risperidone (Risperdal, Janssen-Ortho) may be associated with pituitary tumors, researchers say. In the June 2006 issue of Pharmacotherapy, the team notes that while they haven't uncovered a causal relationship between the drugs and tumors, clinicians and patients should be aware of this important adverse effect.
Antipsychotic Drug
|
Pituitary Tumor
|
Hyperprolactinemia
|
Galactorrhea
|
Amenorrhea
|
Gynecomastia
|
Risperidone
|
54
|
702
|
530
|
445
|
118
|
Olanzapine
|
11
|
37
|
17
|
21
|
23
|
Haloperidol
|
9
|
32
|
49
|
24
|
28
|
Ziprasidone
|
6
|
12
|
13
|
2
|
4
|
Clozapine
|
4
|
15
|
16
|
17
|
7
|
Quetiapine
|
1
|
13
|
12
|
3
|
5
|
Aripiprazole
|
0
|
5
|
5
|
2
|
4
|
Total
*
|
77
|
796
|
630
|
503
|
186
|
Medscape Medical News © 2006 Medscape
Cite this: Allison Gandey. Antipsychotic Drugs Linked to Pituitary Tumors - Medscape - Jun 03, 2006.
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