"Natural" or Alternative Medications for Migraine Prevention

Randolph W. Evans, MD; Frederick R. Taylor, MD

Disclosures

Headache. 2006;46(6):1012-1018. 

In This Article

Summary

What CAM can be stated to be evidence-based? There currently is at best Grade B evidence for all the agents discussed except melatonin, for which there are no data whatsoever. Grade B represents limited evidence from a single randomized trial, or nonrandomized trials or multiple trials with inconsistent outcomes. I have restricted my discussion to RCTs or systematic reviews with individual standard evidence grade summary. Data are inadequate for meta-analysis. No firm consensus yet exists as to the relative treatment efficacy of these agents, but given the number of patients, data consistency, or lack thereof, I would tentatively suggest that the rank order may be: Petadolex ≥ Magnesium > Feverfew (no commercially available MIG-99 forms known to this author) > Riboflavin > CoenzymeQ10 >> Melatonin.


CLICK HERE for subscription information about this journal.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....