"Natural" or Alternative Medications for Migraine Prevention

Randolph W. Evans, MD; Frederick R. Taylor, MD


Headache. 2006;46(6):1012-1018. 

In This Article


Melatonin is implicated in migraine in many ways, from sleep-related associations to seasonal circ-annual effects. Six studies have reported on 1 or another association of melatonin with migraine, with 4 revealing lower levels of melatonin either at baseline, during an acute attack, with insomnia, or without the normally expected increases late in the luteal phase of menstrual migraine.[43] Regardless, there has been no randomized, controlled treatment trial involving melatonin administered to migraineurs.


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