Melatonin is implicated in migraine in many ways, from sleep-related associations to seasonal circ-annual effects. Six studies have reported on 1 or another association of melatonin with migraine, with 4 revealing lower levels of melatonin either at baseline, during an acute attack, with insomnia, or without the normally expected increases late in the luteal phase of menstrual migraine. Regardless, there has been no randomized, controlled treatment trial involving melatonin administered to migraineurs.
Headache. 2006;46(6):1012-1018. © 2006 Blackwell Publishing
Cite this: "Natural" or Alternative Medications for Migraine Prevention - Medscape - Jun 01, 2006.