"Natural" or Alternative Medications for Migraine Prevention

Randolph W. Evans, MD; Frederick R. Taylor, MD


Headache. 2006;46(6):1012-1018. 

In This Article

Coenzyme Q10

On the Internet, CoQ10 has been labeled an "energy enhancer" because, like riboflavin, it plays a role in electron transport. CoQ10 has been used in neurologic and non-neurologic conditions and is considered to have an acceptable safety and tolerance profile at all doses studied to date. Currently, only 1 RCT exists, which was not dose-ranging, and while statistically favorable results were recorded, this fails to make a solid evidence base for the supplement (Grade B evidence for a single RCT and another favorable open-label pilot study).

Sándor et al reported an RCT involving 42 subjects given either a noncommercially available liquid formulation of water-dispersed nanoparticles comprising a supercooled melt of CoQ10 with modified physicochemical properties taken 300 mg/day divided TID or placebo.[42] Migraine attack frequency in month 4 was reduced ≥50% in 47.6% of patients in the active arm as compared to 14.4% for placebo.

Adverse events in this trial were not statistically different between the 2 treatment groups. One patient withdrew and was not considered in the analysis due to "cutaneous allergy."


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