Ovarian Hormones and Migraine Headache: Understanding Mechanisms and Pathogenesis--Part 2

Vincent T. Martin, MD; Michael Behbehani, PhD

Disclosures

Headache. 2006;46(3):365-386. 

In This Article

Endocrinology Of The Menstrual Cycle

The menstrual cycle is divided into follicular and luteal phases. The follicular phase includes all days from the first day of menstrual bleeding to the day before ovulation and the luteal phase includes all days from the first day of ovulation to the last day before the next menstrual period. The follicular and luteal phases can further be subdivided into early, mid, and late time intervals. Serum estradiol levels typically are low during the early to mid-follicular phases (eg, 25 to 50 pg/mL range), peak during the late follicular and early luteal phase (eg, 100 to 400 pg/mL range), plateau during the mid-luteal phase (200 to 300 pg/mL range), and fall precipitously to levels of 25 to 50 pg/mL just prior to menstruation. Serum progesterone levels are extremely low during the follicular phase (<1 ng/mL range), peak during the mid-luteal phase at levels ranging from 6 to 10 ng/mL, and then fall precipitously to levels <2 ng/mL during the late luteal phase (Figure 1).

Changes in serum estrogen and progesterone levels during a native menstrual cycle. Day 1 is the first day of menses and day 27 is the last day before the next menstrual period. The follicular phase includes all days prior to ovulation and the luteal phase includes all days after ovulation. The follicular and luteal phases can be divided into early, mid, and late time periods.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....