Ovarian Hormones and Migraine Headache: Understanding Mechanisms and Pathogenesis--Part 2

Vincent T. Martin, MD; Michael Behbehani, PhD


Headache. 2006;46(3):365-386. 

In This Article

Genetics Of Ovarian Hormones Receptors

Migraine may only be influenced by ovarian hormones in those with a specific genetic predisposition. Colson et al[128] demonstrated that G594A polymorphism of the α-estrogen receptor occurred more frequently in migraineurs than controls within an Australian cohort. They later reported that a 306 base pair insertion within intron 7 of the progesterone receptor gene (PROGINS allele) was overrepresented within migraine patients.[129] The G594A α-estrogen receptor and the PROGINS alleles may act synergistically to increase the prevalence of migraine. Individuals possessing both risk alleles were 3.2 times more likely to have migraine headache than those possessing no alleles while those possessing just the PROGINS allele were only 1.8 times more likely to have migraine. Therefore, polymorphisms of estrogen and progesterone receptors genes may influence migraine prevalence in some populations.


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