Muscle symptoms are a relatively common, and the most potentially hazardous, complaint of patients taking statin medications. These include a range of conditions from muscle pain or weakness through frank rhabdomyolysis. In August of 2001, cervastatin was taken off the US market because of a fatal rhabdomyolysis rate of greater than 3 patients per one million prescriptions.
The underlying pathophysiology of statin-induced muscle disorders is not well understood and is the subject of much debate in the medical literature.[2,3] It is clear, however, that these complications are dose related and have several predisposing factors associated with them.
South Med J. 2006;99(3):250-254. © 2006 Lippincott Williams & Wilkins
Cite this: Primary Evaluation and Management of Statin Therapy Complications - Medscape - Mar 01, 2006.