Type 2 Diabetes in Children and Adolescents - The Next Epidemic?

Eva M. Vivian


Curr Med Res Opin. 2006;22(2):297-306. 

In This Article

Future Studies

To date, specific treatment algorithms for the management of type 2 diabetes in children have not been investigated. The Treatment Options for Diabetes in Adolescents and Youths (TODAY) trial is a multicenter, randomized study investigating the best treatment options in pediatric subjects with type 2 diabetes. The trial enrolled 750 youths, between the ages of 10-17 years, diagnosed with type 2 diabetes within the previous 2 years. Patients will complete a 'run-in' phase, which involves intensive diabetes education for 2-6 months. This education will include glucose monitoring, record keeping, and medication adherence. Patients who successfully achieve an HbA1c of < 8% on metformin 1000-2000mg PO daily during the run in phase of the trial will be randomized to one of three groups: (1) metformin plus lifestyle modification; (2) metformin plus rosiglitazone; or (3) metformin alone for 2-5 years. The lifestyle modification component of the study consists of a weight loss and physical activity program and weekly meetings with a designated counselor for 24 weeks, before transitioning into a maintenance program for the duration of the study. The TODAY trial will provide valuable information regarding the benefits of lifestyle modification and medication in achieving glycemic control in the pediatric population.[42]


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