Congenital Adrenal Hyperplasia in Adults: A Review of Medical, Surgical and Psychological Issues

Clinical Background

The Middlesex Hospital in London follows a cohort of 111 adults (80 female) with classical CAH, comprising 105 with 21-hydroxylase deficiency, four with 11β-hydroxylase deficiency, one with 3βhydroxysteroid dehydrogenase deficiency, one with 17α-hydroxylase deficiency and one with StAR protein deficiency. The median (range) of the cohort was 33 years (18–64), with a median (range) follow-up of 4 years (0–21).

Of the 105 with 21-hydroxylase deficiency, 76 had salt-wasting presenting within the first year of life and 29 were nonsalt-wasting or classic simple virilizing presenting by the age of 9 years. The median (range) body mass index (BMI) was 25·4 kg/m² (18–39·9) for women and 24·9 kg/m² (19·4–31·2) for men. Median (range) height was 1·55 m (1·44–1·71) for women and 1·65 m (1·57–1·82) for men.

Clin Endocrinol. 2006;64(1):2-11. © 2006 Blackwell Publishing

Cite this: Congenital Adrenal Hyperplasia in Adults: A Review of Medical, Surgical and Psychological Issues - Medscape - Jan 01, 2006.