Staphylococcus Aureus Pneumonia: Emergence of MRSA in the Community

Suzanne F. Bradley, MD


Semin Respir Crit Care Med. 2005;26(6):643-649. 

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Other Treatment Strategies for CA-MRSA

Antistaphylococcal antibodies and inhibition of toxin production have also been suggested as additional strategies for the treatment of CA-MRSA.[9,61] Anti-PVL antibodies have been detected in commercial preparations of IgG, and inhibition of the leukocidin has been achieved in vitro.[61] However, the efficacy of IgG in severe staphylococcal infections overall has not been established.[43] Use of clindamycin to inhibit toxin production by CA-MRSA has also been suggested but has not been studied. Surgical drainage of empyema and debridement of necrotic tissue are also important in the treatment of toxin-mediated infection. Treatment with recombinant activated protein C (Xigris; Eli Lilly and Company, Indianapolis, Indiana) for associated septic shock should also be considered.[43]


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