Update on Rotavirus Vaccines

Joseph S. Bresee, MD, FAAP; Umesh D. Parashar, MBBS, MPH; Marc-Alain Widdowson, VetMB, MSc; Jon R. Gentsch, PhD; A Duncan Steele, PhD; Roger I. Glass, MD, PhD

Disclosures

Pediatr Infect Dis J. 2005;24(11):947-952. 

In This Article

Abstract and Introduction

Rotavirus was discovered in 1973, and 10 years later the first report of a rotavirus vaccine clinical trial appeared. This update reviews the epidemiology of rotavirus infections, assesses past and current vaccines and presents ideas for implementation of vaccination programs in developed and developing countries.

Within a decade of the discovery of rotavirus in 1973,[1] the first rotavirus vaccine trial was conducted among children in Finland with a live, attenuated bovine rotavirus strain administered orally.[2] The success of this trial led to optimism that vaccines against this most common agent of severe childhood gastroenteritis worldwide would soon be available. More than 2 decades later, the promise of rotavirus vaccines is beginning to be realized. In this review, the rationale for rotavirus immunization and an update on current vaccine approaches and candidates will be provided.

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