Hypersensitivity Reactions to Vaccine Components

Noushin Heidary; David E. Cohen


Dermatitis. 2005;16(3):115-120. 

In This Article


Adverse reactions to vaccines can be local or systemic and can be immediate or delayed in onset. Contact hypersensitivity reactions to vaccine constituents in susceptible individuals can be identified by patch testing. A positive patch-test reaction to a vaccine component often does not necessarily preclude vaccine administration. Vaccine administration is possible despite patch-test positive results to the aforementioned chemicals because either the component is present in insignificant amounts that are insufficient to provoke elicitation or because the vaccine is given intramuscularly or subcutaneously—routes of administration not commonly associated with allergic contact dermatitis. The risk assessment of vaccination in known allergic individuals should include the information contained herein.

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