Intrapartum Complications Associated With Malformations of Cortical Development

Maria Augusta Montenegro, MD, PhD; Fernando Cendes, MD, PhD; Helena Saito, MD; Jéssica G. Serra, MD; Camila F. Lopes, MD; Ana Maria S. Piovesana, MD, PhD; Helaine Milanez, MD, PhD; Marilisa M. Guerreiro, MD, PhD


J Child Neurol. 2005;20(8):675-678. 

In This Article


Seventy patients (33 girls) with ages ranging from 2 months to 18 years (mean 6.5 years) were evaluated. Three patients had subcortical laminar heterotopia (double-cortex syndrome), 5 had hemimegalencephaly, 10 had polymicrogyria, 12 had lissencephaly/agyria-pachygyria, and 40 had schizencephaly (Figure 1).

Malformations of cortical development. Coronal T1-weighted inversion recovery images showing (A) bilateral perisylvian polymicrogyria; (B) bilateral schizencephaly; (C) subcortical laminar heterotopia (double cortex); and (D) lissencephaly/agyria-pachygyria.

Table 1 shows the characteristics of the patients. Intrapartum complications were reported by 22 (31.5%) patients, reduced fetal movement by 8 (11%) patients, and 7 (10%) patients were previously diagnosed as being asphyxiated at birth (see Table 1 ). Only two (4%) patients in the disease control group presented intrapartum complications (P < .001).

Diseases that might be associated with birth complications were hypertension (n = 3), urinary tract infection (n = 2), alcohol or drug addiction (n = 2), diabetes (n = 1), and cardiac disease (n = 1).


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