Nosocomial Infections Due to Multidrug-Resistant Pseudomonas Aeruginosa: Epidemiology and Treatment Options

Marilee D. Obritsch, PharmD; Douglas N. Fish, PharmD, FCCM; Robert MacLaren, PharmD; Rose Jung, PharmD


Pharmacotherapy. 2005;25(10):1353-1364. 

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Infection Control

A rapid rise in MDRPA infections in non-outbreak settings is a threat that clinicians worldwide will be fighting in the years to come. However, outbreak situations with MDRPA strains within institutions remain a concern. Clonal dissemination has been linked to negligent hygiene issues and contaminated tap water[7] or equipment.[61] An improvement in infection control measures, including hand hygiene, revised equipment procedures, and isolation precautions, have been used to eliminate outbreaks.

Surveillance of institution-specific resistance patterns is a crucial component of early detection of strains and may have a substantial impact on nosocomial infection rates.[62] Another consideration is the variation in susceptibilities between units within individual institutions, as differences have been reported when comparing whole hospital antibiogram data with intensive care unit-specific antibiogram data.[63] Surveillance of this nature allows problems within units to be identified more quickly than waiting for a change in hospitalwide susceptibility data. As MDRPA infection rates rise, active infection control teams and surveillance programs will play a crucial role in early detection, treatment, and, we hope, containment of such infections.


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