Protective Effects of Angiotensin II Interruption: Evidence for Antiinflammatory Actions

Nigel J. Dagenais, B.Sc.(Pharm.); Fakhreddin Jamali, Ph.D.


Pharmacotherapy. 2005;25(9):1213-1229. 

In This Article


Evidence has indicated that angiotensin II is a potent proinflammatory mediator with growth and remodeling effects. In vitro and in vivo studies have shown that angiotensin II blockade significantly reduces concentrations of proinflammatory mediators and oxidative stress products in numerous inflammatory models. Treatment with ACE inhibitors and ARBs demonstrate benefits in ischemia, heart failure, and diabetes. These agents also show promise in the treatment of inflammatory conditions such as rheumatoid arthritis. In addition, angiotensin II suppression could have a therapeutic role for transplant recipients and patients with diseases such as asthma and cancer. Large, prospective, randomized, placebo-controlled studies are necessary to support these findings. Nevertheless, angiotensin II interruption as antiinflammatory pharmacotherapy may have indications far beyond cardiovascular diseases.