Vitamin K in the Treatment and Prevention of Osteoporosis and Arterial Calcification

Jamie Adams; Joseph Pepping


Am J Health Syst Pharm. 2005;62(15):1574-1581. 

In This Article

Vitamin K for Osteoporosis: Rationale

A number of human-cell studies have helped define the role of vitamin K and osteocalcin in bone health. Both phylloquinone and menaquinone promote bone mineralization; however, menaquinone has been shown to be more potent,[34] likely because of the enhanced carboxylation of osteocalcin by menaquinone. Menaquinone has been shown to increase osteocalcin accumulation on the cell layer.[34] In vitro, phylloquinone and menaquinone (MK-4) inhibit osteoclast formation and induce the differentiation of osteoprogenerator cells into osteoblasts.[35]

The results of recent human and animal studies have suggested that concurrent use of menaquinone and vitamin D may substantially reduce bone loss.[9,36,37] In rats with ovariectomy-induced bone loss, menaquinone and vitamin D3 had a synergistic effect on bone-loss reduction.[9] Hirano and Ishii[37] found that the coadministration of calcium, menaquinone, and vitamin D in rats increased the peak bone mass and reduced the loss of bone mineral density (BMD).


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