Inhaled Insulin for Diabetes Mellitus

Tarun K. Mandal


Am J Health Syst Pharm. 2005;62(13):1359-1364. 

In This Article

Patient Acceptance and Compliance

Results of numerous clinical trials with inhaled insulin have shown a high degree of patient compliance and acceptance.[34,35,36,37] Preliminary data indicate that patients converting from insulin injections to inhaled insulin (via AERx iDMS) showed higher compliance, demonstrated by improved glycemic control.[14]

In a recent study, Freemantle et al.[37] examined the impact of the availability of inhaled insulin on patient acceptance. The study was conducted in seven countries, including the United States. Patients with type 2 diabetes who could not control their blood glucose levels by diet changes or oral therapy were randomized to two groups. Both groups (A and B) received counseling on current available treatment options. Group B also received information about inhaled insulin as a potential treatment option. The patients were then asked to choose a therapy, including no change in their current treatment. In group B, 43.2% of the participants chose a treatment option that included insulin, compared with only 15.5% in group A. Inhaled insulin was the most frequently chosen option in group B (35.3%). The results of this study suggest that the availability of inhaled insulin as a potential treatment may increase patients' willingness to add or change to more appropriate therapy, including insulin.