Atypical Manifestations of Gastroesophageal Reflux Disease

Michael F. Vaezi, MD, PhD, MSEpi


October 27, 2005

In This Article

Concluding Remarks

GERD and extraesophageal symptoms have a complex relationship. In many patients who have extraesophageal symptoms, reflux of acid or nonacid gastroduodenal contents may be a causal factor. However, in many others, although GERD may be implicated, reflux disease may play a minimal role. The current diagnostic tests lack specificity to help unravel this complex association. Thus, empiric therapy is currently the most specific tool to determine whether reflux disease is playing a significant role in patients' extraesophageal symptoms. The current recommendation in such patients is therapy with PPIs for at least 2-3 months. In those who respond to therapy, tapering the degree of acid suppression is the next step, whereas in those unresponsive to PPI therapy, causes other than GERD should be sought.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.