Serum Antibodies to Oral Anaerobic Bacteria in Patients With Rheumatoid Arthritis

Mesut Ogrendik, MD; Siranus Kokino, MD; Ferda Ozdemir, MD; Philip S. Bird, BSc, MSc, PhD; Stephen Hamlet, BSc, MSc

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In This Article

Results

The results are shown in Table 1 . The RA patients had significantly elevated IgG antibodies to P gingivalis ( P < .001), P intermedia ( P < .001), P melaninogenica ( P < .01), and B forsythus ( P < .05) when compared with healthy controls. The antibody levels to A actinomycetemcomitans ( P > .05) did not display any significant difference between the 2 levels.

The mean ESR was 52.8 mm/h (SD ± 13.8), and serum CRP was 32.0 mg/L (±10.6) in patients with RA. The mean DAS28 score was 4.2 ± 1.3 in RA patients. RF was strongly positive in serum samples obtained from all patients with RA. The median morning stiffness duration of all patients was 60 minutes. Extra-articular manifestations (rheumatoid nodules and anemia) have been demonstrated in 6 of 30 RA patients (20%). Vasculitis has been demonstrated in 1 of 30 RA patients (3.3%).

A positive correlation between serum IgG antibody levels against P gingivalis and serum CRP was clearly detected in patients with RA ( r = .795; P = .000; Figure 1). There was significant correlation between serum IgG antibody levels against P intermedia and ESR ( r = .809; P = .000) (Figure 2). In RA patients, there was no significant correlation between IgG antibody levels against P melaninogenica, B forsythus, and the acute-phase reactants ESR or serum CRP ( P melaninogenica IgG: ESR: r = .019, not significant [NS], CRP: r = -.141, NS; B forsythus IgG: ESR: r = .173, NS, CRP: r = .147, NS; data not shown).

Poryphyromonas gingivalis and serum C-reactive protein detected in patients with rheumatoid arthritis.

Correlation between serum immunoglobulin (Ig)G antibody levels against Prevotella intermedia and erythrocyte sedimentation rate.

There was no significant correlation between IgG antibody levels against oral anaerobic bacteria and disease duration and age of patients ( P gingivalis IgG: disease duration: r = +.157, NS, age: r = +.119, NS ; P intermedia IgG: disease duration: r = -.132, NS, age: r = +.166, NS; P melaninogenica IgG: disease duration: r = +.031, NS, age: r = +.112, NS; B forsythus IgG: disease duration: r = +.023, NS, age: r = +.127, NS).

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