Quality of Life and Antihypertensive Drug Therapy

Joel Handler, MD

In This Article

Combination Therapy to Reduce Adverse Effects and Increase Compliance

One of the ways compliance can be improved is by using a combination tablet. A study has demonstrated improved persistence with prescription refills and patient compliance using a combination pill (Figure 10). Lisinopril/HCTZ combination was compared with separate lisinopril and HCTZ tablets. At the end of a year, there was an 18.8% difference in persistence favoring the combination pill.[44]

Drug persistence rates at 12 months in newly diagnosed hypertensive patients administered lisinopril and hydrochlorothiazide (HCTZ) as two separate pills (lisinopril) vs. a single combination tablet (lisinopril/HCTZ). Reprinted with permission from Manag Care. 2000;9(9 suppl):S2-S6.[44]