Combination Therapy to Reduce Adverse Effects and Increase Compliance
One of the ways compliance can be improved is by using a combination tablet. A study has demonstrated improved persistence with prescription refills and patient compliance using a combination pill (Figure 10). Lisinopril/HCTZ combination was compared with separate lisinopril and HCTZ tablets. At the end of a year, there was an 18.8% difference in persistence favoring the combination pill.
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Cite this: Quality of Life and Antihypertensive Drug Therapy - Medscape - May 01, 2005.