Evolution of C-Reactive Protein as a Cardiac Risk Factor

Paula J. D'Amore, PhD, D(ABMLI)

Disclosures

Lab Med. 2005;36(4):234-238. 

In This Article

CRP and the Metabolic Syndrome

The metabolic syndrome, as defined by the National Cholesterol Evaluation Program (NCEP) and the World Health Organization (WHO), is a cluster of conditions known to increase the risk of developing diabetes, CVD, or stroke.[5,25] The presence of 3 of the following is defined as the metabolic syndrome: dyslipidemia (elevated triglycerides, low HDL-cholesterol), abdominal obesity, hypertension, and impaired fasting glucose. Several studies have addressed the association of chronic, low-grade inflammation, as defined by levels of hsCRP, with the metabolic syndrome. According to data from the third National Health and Nutrition Examination Survey (NHANES III), 24% of the population in the United Stated has at least 3 of the components of the metabolic syndrome and hsCRP levels increased as the number of metabolic syndrome conditions were present.[26] The prevalence of the metabolic syndrome increased with age and was highest among Mexican American women. Similar results linking high levels of hsCRP to the metabolic syndrome were seen in the WHS study and the Insulin Resistance Atherosclerosis Study.[27,28] In the WHS, there was an increase in the rate of future CVD as the hsCRP levels increased in subjects with metabolic syndrome.[27]

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