Statins and Osteoporosis: A Clinical Review

Michael J. Gonyeau, Pharm.D.


Pharmacotherapy. 2005;25(2):228-243. 

In This Article


Osteoporosis, a leading public health threat, affects approximately 44 million people in the United States. Most available treatment works to prevent further bone loss, improve BMD, and reduce the risk of fractures, but it has not been proved to increase bone formation. Statins may be able to build bone and thus are being studied for the treatment of osteoporosis. In vitro, in vivo, and animal studies have shown positive effects on bone mineralization and reductions in bone resorption, but clinical data on surrogate markers and fracture rates are conflicting. Thus, the use of statins in the prevention of fractures or the treatment of osteoporosis requires further study.


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