The Mechanism of Action of Omega-3 Fatty Acids in Secondary Prevention Post-Myocardial Infarction

Nigel Harrison; Brihad Abhyankar


Curr Med Res Opin. 2005;21(1):95-100. 

In This Article


This brief review suggests that omega-3 fatty acids play a significant role in secondary prevention post-MI. The mechanisms through which EPA and DHA exert their action are distinct and adjuvant to the available standard secondary prevention therapies. However, more conclusive RCTs are needed on the quantification of this effect and also for more clarity on the exact mechanism of action.

Omega-3 fatty acid supplementation advice is beginning to appear in various international guidelines. One gram per day of EPA + DHA has been strongly recommended by the latest American Heart Association (AHA) guidelines[58] as well the European Society of Cardiology (ESC) guidelines for secondary prevention after ST elevation MI.[59]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: