The Place of Botulinum Toxin Type A in the Treatment of Focal Hyperhidrosis

N. Lowe; A. Campanati; I. Bodokh; S. Cliff; P. Jaen; O. Kreyden; M. Naumann; A. Offidani; J. Vadoud; H. Hamm


The British Journal of Dermatology. 2004;151(6) 

In This Article

Other Types of Focal Hyperhidrosis

Botulinum toxin type A treatment has been used to treat a variety of other hyperhidrosis conditions and in the treatment of distinct dermatological disorders or syndromes associated with hyperhidrosis. Doses of 30 U botulinum toxin type A injected into the hyperhidrotic area of the forearm in a patient with localized unilateral hyperhidrosis revealed complete anhidrosis (Evidence level: III).[5] Botulinum toxin type A is also widely used with excellent efficacy for gustatory sweating (Frey's syndrome) and some recommend this option as first-line treatment (Evidence level: IIb).[43] Its use has also been suggested in the treatment of Ross syndrome (progressive segmental anhidrosis) (Evidence levels: IIb, III).[44,45]

Frontal hyperhidrosis has been successfully treated with botulinum toxin type A, with a reduction in sweating of approximately 75% seen for a period of at least 5 months (Evidence level: IIb).[46] Schnider et al. also demonstrated that BOTOX® significantly reduces sweat production in focal hyperhidrosis over a period of 13 weeks following a single injection (Evidence level: Ib).[47]