Long-Term Malaria Prophylaxis for Travelers

Jürgen Knobloch

In This Article


In individual cases of long-term travel to malaria-endemic regions, it may be difficult to compromise between our more or less evidence-based medical recommendation and the compliance to be expected from the traveler. When accompanied with appropriate information on the respective malaria situation, more general prophylaxis methods are easily accepted, whereas the long-term use of drugs is not. Thus, even for high-transmission areas, it may be indicated to recommend chemoprophylaxis at intervals, for example, in periods of high malaria transmission during the rainy season or during trips from low- to high-transmission areas.[1] In summary, the following issues should be considered for long-term travelers to hyper- and holoendemic malaria regions:

  • Give appropriate information on the respective malaria situation.

  • Encourage exposure prophylaxis including spraying of the residence and control of mosquito breeding grounds.

  • Give information on the drugs appropriate for the individual case.

  • Encourage chemoprophylaxis for periods of high transmission.

  • Encourage standby treatment for periods without chemoprophylaxis.

  • Make sure that GMP drugs are used for chemoprophylaxis and standby treatment.

  • Take caution in recommending local clinics for malaria testing if there is no information on the quality standard.

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This article was presented at the 8th Conference of the International Society of Travel Medicine (CISTM8), in New York, New York, USA, on May 11, 2003.