COMMENTARY

"Bipolarity" in the Setting of Dementia: Bipolar Type VI?

Hagop S. Akiskal, MD; Olavo Pinto, MD; Diogo R. Lara ,MD, PhD

January 06, 2005

Introduction

Bipolar disorder and dementia have been regarded as distinct clinical entities. In contrast to unipolar depression, bipolar spectrum disorders as a rule have been neglected in the differential diagnosis of dementia. In this paper, we discuss the clinical picture of patients who present mood instability of very late onset, mimicking dementia, and sketch out a series of common clinical and neurobiological points suggesting a closer link between these disorders than previously thought.

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