Caloric Restriction and Life Expectancy

Highlights of the 5th European Molecular Biology Organization Interdisciplinary Conference on Science and Society -- Time & Aging: Mechanisms and Meanings; November 5-6, 2004; Heidelberg, Germany

Elena Armandola, PhD

Introduction

Tell me what you eat, and I'll tell you how long you'll live...

These words may sound like the lines of a song, but they actually reflect one of the most debated issues in our current understanding of the biology of aging, as presented at the European Molecular Biology Organization (EMBO) conference recently held in Heidelberg, Germany, on "Time & Aging: Mechanisms and Meanings."

Can diet help to prolong the expected lifespan of healthy individuals?

The experiments done in rodents and other short-lived species that link a hypocaloric diet to a longer lifespan are well known. Can the information obtained in rodents be extrapolated to humans, and does it help to find "rules" that would lead to increased lifespans?

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