Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden?

Hélène Feillet; Jean-François Bach


Curr Opin Gastroenterol. 2004;20(6) 

In This Article


Bacterial infections represent candidate etiologic factors in IBD. Epidemiologic and experimental data indicate that bacteria (and parasites) also appear to have a non-specific protective role on IBD, similar to that described in autoimmune and allergic diseases (the hygiene hypothesis). The underlying mechanisms are still ill defined, including homeostatic regulation and stimulation of toll-like receptors (TLR). These concepts pave the way to new therapeutic approaches such as probiotics or TLR ligands.


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