Diuretic-Related Side Effects: Development and Treatment

Domenic A. Sica, MD

In This Article


Diuretic-related side effects occur more commonly with loop and/or K+ -sparing agents and are less so with thiazide-type diuretics, as they are currently used in the treatment of hypertension. Diuretic-related side effects, particularly with loop and/or K+ -sparing agents, are not uncommon causes for hospitalization due to hypotension, renal impairment, electrolyte disturbances, and gout in the context of hospital admissions prompted by adverse drug reactions.[89] Many diuretic-related side effects can be avoided or effectively tempered by selection of the lowest dose necessary for effective BP and/or volume control.