Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options

Carissa E. Mancuso, PharmD; Maria G. Tanzi, PharmD; Michael Gabay, PharmD


Pharmacotherapy. 2004;24(9) 

Literature Evaluation: Adults

The medical literature contains a multitude of reports of paradoxical reactions to benzodiazepines in adults. The first such report, published in 1960, involved a patient receiving chlordiazepoxide.[8] Since then, several reports have described these reactions in association with more commonly used agents from the benzodiazepine class. For this review, English language-only literature on both adult and pediatric cases was identified through a MEDLINE search (January 1966- January 2004), secondary literature databases, and bibliographies of pertinent articles. Table 1 [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17] summarizes the more recent reports in adults.