The Effect of Sildenafil Citrate on Uterine and Clitoral Arterial Blood Flow in Postmenopausal Women

Erkan Alataş, MD; A. Baki Yağci, MD

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In This Article

Results

Table 1 shows the results of the color Doppler sonography measurements and statistical analysis. At least 1 of the uterine arteries was visualized, and satisfactory recordings of the Doppler signals from the uterine arteries were obtained in all subjects. Before sildenafil administration, the mean resistance and pulsatility indexes of the uterine arteries studied were 0.80 ± 0.07 and 2.08 ± 0.52, respectively. Clitoral artery circulation was easily detectable by color Doppler sonography, and good quality flow velocity waveforms were obtained. The basal mean peak systolic velocity, resistance index, and pulsatility index of the clitoral arteries studied were 12.9 ± 5.8 cm/sec, 0.80 ± 0.11, and 2.44 ± 1.32, respectively.

One hour after the administration of a single oral dose of 50 mg sildenafil citrate, the mean uterine arterial resistance index (0.73 ± 0.08) and pulsatility index (1.66 ± 0.50) were significantly lower and the mean peak systolic velocity of the clitoral arteries (17.9 ± 8.6 cm/sec) was significantly higher compared with baseline values (P < .001). Sildenafil did not cause any significant change in the mean resistance index (0.79 ± 0.10) and pulsatility index (2.51 ± 1.44) of the clitoral artery (P = .683 and P = .714, respectively).

After sildenafil administration, we observed side effects including headache (n = 4), dizziness (n = 2), flushing (n = 2), and tachycardia (n = 1), none of which were serious.

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