Smallpox: What the Dermatologist Should Know

Phyllis I. Spuls, MD; Jan D. Bos, MD, PhD; Donald Rudikoff, MD


Skinmed. 2004;3(4) 

In This Article

Generalized Vaccinia

Generalized vaccinia, from hematogenous dissemination of vaccinia virus, displays a widespread macular and papular or vesicular eruption about 6-9 days after primary vaccination.[50] It occurs in about one in every 5000 vaccinations. Although usually self-limited and not requiring treatment in persons with normal immunity, it may cause severe toxicity in immunocompromised individuals and require VIG treatment.


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