Antimicrobial Stewardship Programs as a Means to Optuimize Anitmicrobial Use

Robert C. Owens, Jr., Pharm.D.; Gilles L. Fraser, Pharm.D., FCCM; Patricia Stogsdill, MD


Pharmacotherapy. 2004;24(7) 

In This Article


Antimicrobial stewardship programs, whose goal is to improve the use of antimicrobials at the institutional level, have been successful. Two dominant strategies exist for these programs -- prior approval, and concurrent review and feedback. Many issues, including measurable outcomes, barriers, funding, and personnel, must be identified before a program is implemented. In addition, several areas for future research should be considered: standardization of outcome measures and their definitions, application of newer analytic methods (e.g., interrupted time series analysis) to distinguish significant changes in before-and-after studies, multicenter studies, and determination of safety and efficacy of these programs in pediatric populations.