Great progress has been made in the past 2 decades toward understanding the molecular genetics of CRC. Intense, ongoing research continues to shed light on new mechanisms of colorectal tumorigenesis. Despite this progress, there remains a relatively large population of individuals who have heritable CRC but an as yet unidentified genetic etiology. Advanced genetic testing hints at the vast potential of screening at-risk individuals, while, at the same time, the pitfalls of false-negative results remain to be addressed. An exciting future awaits us in the clinical application of new research and novel technologies that will ultimately lead to the universal goal -- better health for all.
This work was in part supported by grants from the National Institutes of Health (DK52230 and CA84197).
© 2004 Medscape
Cite this: Genetics of Colorectal Cancer - Medscape - Aug 13, 2004.