Genetics of Colorectal Cancer

Irfan M. Hisamuddin, MD; Vincent W. Yang, MD, PhD

In This Article


Great progress has been made in the past 2 decades toward understanding the molecular genetics of CRC. Intense, ongoing research continues to shed light on new mechanisms of colorectal tumorigenesis. Despite this progress, there remains a relatively large population of individuals who have heritable CRC but an as yet unidentified genetic etiology. Advanced genetic testing hints at the vast potential of screening at-risk individuals, while, at the same time, the pitfalls of false-negative results remain to be addressed. An exciting future awaits us in the clinical application of new research and novel technologies that will ultimately lead to the universal goal -- better health for all.


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